Chronic inflammation accelerates epigenetic aging: transposon and HIV virus-associated aging
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Chronic inflammation as a contributor to aging is not an especially new idea. Here, too, epigenetic clock evidence does seem to see this relationship. There is also evidence that HIV accelerates epigenetic aging.
Steve: I mean, I've seen results from other groups, you know, that look at that issue, chronic inflammation or even looking at these...sorry, what are these...transposons, you know. So, there's some very exciting results that shows that some transposons become active in older tissues, you know, and so I've seen some preliminary data where people said this was associated with increased epigenetic aging. And also, our finding that HIV is very much associated with accelerated epigenetic aging also points again to this idea of a viral component, you know. So, clearly there must be a connection, you know, and it will be very interesting to tease it out. I don't have a good sense how strong that effect is, you know, for example, chronic inflammation, or do these enzymes that you mentioned...how strong is their effect if we perturb it? Do they explain 30% of the variability or just 10%? You know. So, that sense summarize the question.
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