Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health
Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health
Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health.
Get these episodes in a convenient podcast format.
Aliquot episodes make great companion listening for a long drive. You can find these special members-only episodes alongside live recorded Q&As on The Aliquot, our official premium FoundMyFitness podcast.
Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health.
-
Introduction
-
The role of both mTOR and the IGF-1 pathway in cellular growth and their regulation by amino acids (Peter Attia discussion)
-
Living longer as a function of preventing insidious damage to our cells and tissues
-
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans (Valter Longo discussion)
-
Effects of IGF-1 on human lifespan
-
Refeeding that follows fasting mimicking creates an environment that may be just right for the regeneration of healthy cells
-
The growth-longevity trade-off (Rhonda Patrick & Mike Maser discussion)
Hear new content from Rhonda on The Aliquot, our member's only podcast
Listen in on our regularly curated interview segments called "Aliquots" released every week on our premium podcast The Aliquot. Aliquots come in two flavors: features and mashups.
- Hours of deep dive on topics like fasting, sauna, child development surfaced from our enormous collection of members-only Q&A episodes.
- Important conversational highlights from our interviews with extra commentary and value. Short but salient.
Recent Aliquot Episodes
Aliquot #115: A Lifestyle Guide for Mitochondrial Optimization
Mitochondrial health and overall health are intrinsically linked. Identifying ways to boost mitochondrial biogenesis...
Aliquot #114: Supplements & Diet Strategies to Boost Mitochondrial Function
Mitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis...
Aliquot #113: Is resistance training a type of aerobic exercise?
Aerobic exercise and resistance training are essential for optimal health. However, finding the time to do both can be challenging...
Aliquot #112: Approaches to Reverse Hair Loss and Graying
As we age, our hair changes: It often turns gray and becomes finer, and it might even fall out—permanently...
Aliquot #111: Why ultra-processed foods and their additives are harmful
Processed foods fall on a spectrum, from minimally processed (like oatmeal or canned tomatoes) to ultra-processed...