Aliquot #89: Beyond The Amyloid of Alzheimer's — The Vascular Repair Perspective
Aliquot #89: Beyond The Amyloid of Alzheimer's — The Vascular Repair Perspective
Vascular dysfunction, the loss of normal endothelial tone and permeability of blood vessels, is a common feature of most forms of dementia, including Alzheimer's disease. People who carry the APOE4 gene are at greater risk for vascular dysfunction and Alzheimer's disease. Identifying and treating vascular problems in the brain could postpone the onset of cognitive decline and improve the quality of life for people with dementia.
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Vascular dysfunction, the loss of normal endothelial tone and permeability of blood vessels, is a common feature of most forms of dementia, including Alzheimer's disease. People who carry the APOE4 gene are at greater risk for vascular dysfunction and Alzheimer's disease. Identifying and treating vascular problems in the brain could postpone the onset of cognitive decline and improve the quality of life for people with dementia.
In this Aliquot, Dr. Axel Montagne discusses the importance of early detection, the role of vascular dysfunction, and the future of diagnosis in Alzheimer's disease.
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Can targeting vascular dysfunction help delay Alzheimer's disease?
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Is blood-brain barrier leakiness more critical than amyloid in dementia progression?
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Using MRI to detect blood-brain barrier leakiness
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The vulnerability of the hippocampus
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Predicting decline with blood tests and MRI imaging — what if it can be prevented?
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Solving the vascular problems — would it prevent amyloid buildup?
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The delicate nature of pericytes in the aging brain
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Using APOE4 status for targeted intervention
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The future of therapies for pericyte repair
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Early detection for large patient cohorts — has the technology arrived?
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