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  • Drinking coffee may reduce the risk of stroke in women.

    A stroke occurs when blood flow to the brain is interrupted, killing brain cells. It is the second leading cause of disability and death worldwide, affecting the lives of roughly 102 million people. Evidence suggests that inflammation plays an important role in the pathogenesis of strokes. Findings from a 2011 study suggest that coffee reduces the risk of stroke in women.

    Coffee is one of the most consumed beverages worldwide. It is rich in polyphenolic compounds, including quercetin, chlorogenic acid, and others, that exert beneficial health effects in humans. Evidence suggests that coffee reduces inflammation.

    The study involved nearly 35,000 women enrolled in the Swedish Mammography Cohort. The women, who had no history of cardiovascular disease or cancer at the time of their enrollment, completed questionnaires about their coffee consumption and other lifestyle habits. Using hospital medical records, the investigators gathered information about whether the women experienced a stroke during a 10-year follow-up period.

    They found that drinking coffee was associated with a reduced risk of strokes, even after taking other risk factors into consideration, such as smoking, body mass index, diabetes, hypertension, or alcohol consumption. On average, drinking 1 to 2 cups daily reduced risk by 22 percent; 3 to 4 cups reduced risk by 25 percent; 5 or more cups reduced risk by 23 percent.

    These findings suggest that moderate coffee consumption reduces the risk of stroke in women. Other lifestyle behaviors may reduce stroke risk, too, such as sauna use, which may reduce risk by as much as half. Learn more in this presentation by Dr. Rhonda Patrick.

  • Exposure to air pollution increases the risk of stroke by more than half.

    Air pollution contains many toxic substances, including chemicals, gases, and particulate matter – a mixture of solid particles and liquid droplets that exert neuroinflammatory effects. Exposure to air pollution promotes oxidative stress and increases the risk of developing many chronic diseases, such as cardiovascular disease, cancer, hypertension, and diabetes, markedly shortening people’s lives. Findings from a 2003 study suggest that exposure to air pollution is associated with an increased risk of stroke.

    A stroke is a neurological disorder characterized by the interruption of blood flow to the brain. Strokes are typically classified as either ischemic or hemorrhagic. Ischemic strokes, which account for approximately 87 percent of all strokes, are characterized by the blockage of an artery. Hemorrhagic strokes, which account for 13 percent of strokes, are characterized by bleeding from a blood vessel that supplies the brain.

    The researchers reviewed admission data from hospitals in and around Kaohsiung, Taiwan, an industrial area known for its high levels of air pollution. They obtained air quality assessments of the same area via government monitoring stations that provided measurements of gases (sulfur dioxide, nitrogen dioxide, carbon monoxide, and ozone) and particulate matter with diameters of 10 micrograms (PM10) or less. Because weather influences air quality, they also collected humidity and temperature readings from the government weather agency.

    They found that exposure to higher levels of nitrogen dioxide and PM10 was associated with increased risk of stroke, especially on warm days (68°F or warmer). The risk of ischemic stroke increased by 55 percent for greater nitrogen dioxide exposure and by 46 percent for greater PM10 exposure. The risk for hemorrhagic stroke increased by 54 percent with greater exposure to either nitrogen dioxide or PM10.

    These findings suggest that exposure to common air pollutants, especially during warmer weather, increases the risk of stroke. The investigators posited that this increased risk is due to the inflammatory effects of particulate matter and the increase in plasma viscosity and serum cholesterol levels that occur with exposure to high temperatures and humidity.

  • Higher serum magnesium concentrations reduce the risk of having a brain aneurysm.

    A brain aneurysm is a weakness in a blood vessel in the brain that swells and fills with blood. If the aneurysm ruptures, it releases blood into the spaces that surround the brain. This bleeding can cause many complications, including hemorrhagic stroke, brain damage, coma, and even death. Evidence from a 2021 study suggests that higher serum magnesium concentrations reduce the risk of having a brain aneurysm.

    Magnesium is an essential mineral and a cofactor for hundreds of enzymes. Found in green leafy vegetables, nuts, and seeds, magnesium participates in many physiological processes, including energy production, protein synthesis, ion transport, and cell signaling. Magnesium deficiency is linked with an increased risk of cardiovascular disease, osteoporosis, hypertension, and type 2 diabetes. Genetic variants called single nucleotide polymorphisms (SNPs) influence magnesium status.

    The investigators conducted an analysis using Mendelian randomization, a research method that provides evidence of links between modifiable risk factors and disease based on genetic variants within a population. Mendelian randomization is less likely to be affected by confounding or reverse causation than other types of studies, but since it is based on assumptions, the likelihood of the assumptions must be taken into consideration. Their analysis focused on five magnesium-related SNPs identified in a genome-wide association study in nearly 24,000 people of European ancestry. They found that for every 0.1 mmol/L genetically predicted increase in serum magnesium concentration, the risk of having either a ruptured or unruptured brain aneurysm decreased 34 percent.

    These findings suggest that higher magnesium concentrations reduce the risk of having a brain aneurysm. Learn more about the importance of magnesium in this episode featuring Dr. Rhonda Patrick.

  • Exercising 30 minutes a day reduces the risk of a ruptured brain aneurysm.

    Exercise and other forms of physical activity exert profound cardioprotective effects. In fact, people who regularly engage in moderate leisure time physical activity are less likely to develop cardiovascular disease than people who are inactive. Findings from a 2019 study suggest that just 30 minutes of moderate exercise daily reduces the risk of experiencing a ruptured brain aneurysm.

    The bleeding associated with a ruptured brain aneurysm impedes the delivery of oxygen to brain tissue, potentially causing a stroke and impairing cognitive and motor function. Experts estimate that as many as 12 percent of people who experience a ruptured brain aneurysm will die immediately; as many as 45 percent will die within 30 days of the event.

    The study involved more than 65,000 adults enrolled in the FINRISK, an ongoing study of risk factors for chronic diseases among people living in Finland. The investigators collected information about the participants' physical activity, including activities performed during leisure time, commuting, and working. They also reviewed medical records and autopsy registries to identify those who had experienced a ruptured brain aneurysm.

    They found that 543 of the participants experienced a ruptured brain aneurysm during a 42-year period. However, those who engaged in regular physical activity were protected: For every 30-minute increase in weekly leisure-time physical activity, the risk of experiencing a ruptured brain aneurysm decreased by 5 percent. The protective effects of leisure-time activity were observed across all age groups and were particularly strong for smokers. Participants who had an active commute were protected as well, but this protection lessened upon retirement, when they stopped commuting. Interestingly, those who had moderate or high work-related physical activity were 34 to 41 percent more likely to experience a ruptured brain aneurysm.

    These findings suggest that just 30 minutes of moderate leisure-time exercise and physical activity daily exert robust cardioprotective effects, reducing the risk of ruptured brain aneurysm. Learn more about the benefits of exercise in our overview article.

  • From the article:

    Oestrogen helps maintain the structure of blood vessel walls by promoting the division of endothelial cells within the vessel walls, which is important for repair if the vessels become damaged. However, oestrogen levels drop significantly at the menopause.

    Women have been shown to be more likely to develop a cerebral aneurysms after the age of 40 years, and aneurysms are most likely to rupture between the ages of 50 and 59 years.

    The authors asked 60 women with cerebral aneurysms about their use of the oral contraceptive pill and hormone replacement therapy, and this was compared with usage in 4,682 other women drawn from the general public.

    Women with cerebral aneurysms were found to have been significantly less likely to have taken oral contraceptives or hormone replacement therapy. Women with cerebral aneurysms also had an earlier average age of menopause.

    Previous studies have shown that use of the oral contraceptive pill protects against haemorrhagic stroke in later life, while women who start their periods early and/or do not have children are at greater risk.

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  • From the article:

    The average age at which women in both groups had started the menopause was similar, and analysis of the results showed that later menopause and use of hormone replacement therapy (HRT) protected against the risk of a cerebral aneurysm, lessening the risk by 21% and 77%, respectively.

    Premature menopause - before the age of 40 - had occurred in one in four (26%) of the women who had had an aneurysm compared with around one in five (19%) of those in the comparison group.

    And each successive four year increase in the age at which a woman went through the menopause lessened the likelihood of a cerebral aneurysm by around 21%.

    Smoking did not seem to be linked to an increase in risk, while alcohol consumption was of borderline significance.

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  • From the article:

    At this week’s American College of Surgeons meeting in New Orleans, Derek T. Woodrum, M.D., a U-M resident in general surgery, will present new research results showing that smooth muscle cells from aortas of male rats contain 2.5 times more destructive MMP-9 protein and 10 times the level of MMP-9 gene expression compared to the same cells from female rat aortas. Known to be involved in AAA [abdominal aortic aneurysms] formation, MMP-9 is a cell-digesting enzyme that eats away at the wall of the aorta, leaving it vulnerable to expansion and rupture.

    However, when Woodrum treated male rats with estradiol, a form of the female hormone estrogen, and then tested their aortas, he found that MMP-9 activity was substantially decreased. At this year’s meeting, Woodrum will receive an American College of Surgeons “Excellence in Research Award” for his study.

    […]

    “Earlier studies have demonstrated that increased estrogen systemically inhibits the development of AAAs,” Upchurch says. “Dr. Woodrum’s study extends earlier research and suggests that there also is something inherent in males that increases MMP-9 and may lead to greater AAA formation.”

    “Estrogen affects production of MMP-9 by white blood cells called macrophages,” Upchurch adds. “MMPs degrade collagen and elastin, two major proteins in the aortic wall.

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  • From the article:

    “Our data found a previously undescribed causative role for 3-hydroxyanthranilic acid (3-HAA), a product of tryptophan metabolism, in abdominal aortic aneurysm formation,” said Dr. Ming-Hui Zou, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. “We believe agents that alter tryptophan metabolism may have therapeutic potential for preventing or treating abdominal aortic aneurysm. Our findings suggest that reducing 3-HAA may be a new target for treating cardiovascular diseases.”

    The kynurenine pathway is the major route for the metabolism of tryptophan, and other studies have found this pathway plays a key role in the increased prevalence of cardiovascular disease. The researchers sought to identify the role of the kynurenine pathway and its products in angiotensin II (AngII)-induced abdominal aortic aneurysm. AngII is a hormone that increases blood pressure by constricting the blood vessels and is the principal mediator for the development and progression of abdominal aortic aneurysm.

    The researchers generated mice with genetic deficiencies by crossbreeding, and then infused the mice with AngII.

    The study is the first to show that genetic deletion of indoleamine 2,3-dioxygenase (IDO) or the decrease in the gene expression of kynureninase (KNU) in the body restrained AngII-induced abdominal aortic aneurysm in mice deficient in apolipoprotein e.

    In addition, the researchers made the discovery that 3-HAA was responsible for AngII-induced abdominal aortic aneurysm in the body.

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  • From the article:

    Calculating population attributable risk – the fraction of subarachnoid hemorrhages that can be attributed to a particular trigger factor – the researchers identified the eight factors and their contribution to the risk as:

    -Coffee consumption (10.6 percent)

    -Vigorous physical exercise (7.9 percent)

    -Nose blowing (5.4 percent)

    -Sexual intercourse (4.3 percent)

    -Straining to defecate (3.6 percent)

    -Cola consumption (3.5 percent)

    -Being startled (2.7 percent)

    -Being angry (1.3 percent)

    “All of the triggers induce a sudden and short increase in blood pressure, which seems a possible common cause for aneurysmal rupture,” said Monique H.M. Vlak, M.D., lead author of the study and a neurologist at the University Medical Center in Utrecht, the Netherlands.

    Risk was higher shortly after drinking alcohol, but decreased quickly, researchers said.

    […]

    Although physical activity had triggering potential, researchers don’t advise refraining from it because it’s also an important factor in lowering risk of other cardiovascular diseases.

    “Reducing caffeine consumption or treating constipated patients with unruptured IAs with laxatives may lower the risk of subarachnoid hemorrhage,” Vlak said. “Whether prescribing antihypertensive drugs to patients with unruptured IAs is beneficial in terms of preventing aneurysmal rupture still needs to be further investigated.”

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  • From the article:

    The upper safe limit of drinking was about 5 drinks per week (100g of pure alcohol, 12.5 units or just over five pints of 4% ABV2 beer or five 175ml glasses of 13% ABV wine).

    However, drinking above this limit was linked with lower life expectancy. For example, having 10 or more drinks per week was linked with 1-2 years shorter life expectancy1. Having 18 drinks or more per week was linked with 4-5 years shorter life expectancy.

    […]

    The researchers also looked at the association between alcohol consumption and different types of cardiovascular disease. Alcohol consumption was associated with a higher risk of stroke, heart failure, fatal aortic aneurysms, fatal hypertensive disease and heart failure and there were no clear thresholds where drinking less did not have a benefit.

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  • Hypertension is diagnosed when blood pressure on the artery walls is consistently too high. This condition can eventually damage cells of the arteries' inner lining, leading to angina, heart attack, stroke, aneurysm, kidney failure and other serious health problems.

    “People’s occupations during their working years can clearly be a risk for hypertension after they retire,” said senior study author Paul Leigh, a professor with the Center for Healthcare Policy and Research and the Department of Public Health Sciences at UC Davis. “The body seems to have built up a stress reaction that takes years to ramp down and may last well beyond age 75.”

    […]

    What they found with retirees was consistent with studies of those who are currently employed: higher-status occupations are associated with less hypertension than lower-status occupations.

    […]

    Unlike executives and professionals like architects and engineers, Leigh explained, workers in positions such as sales, administrative support, construction and food preparation have little control over decision-making, are under pressure to get a specified amount of work done in a certain amount of time and may feel inadequate about their positions in the workplace hierarchy. Consequently, their stress levels tend to be higher, which can lead to high blood pressure and, eventually, hypertension.

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  • From the article:

    During the past few decades, the genetic makeup has been regarded as playing a significant role in the development of SAH [subarachnoid haemorrhage]. Contrary to this belief, however, a twin study recently published in the journal Stroke showed that environmental factors account for most of the susceptibility to develop SAH Conducted in Finland, Sweden and Denmark, the study is the largest population level twin study in the world.

    This means that instead of screening the close family members of SAH patients, the focus of preventive treatment may now be increasingly shifted to the efficient management of hypertension and smoking cessation intervention. This is what we do with other cardiovascular diseases as well."

    The Nordic study combined data on almost 80,000 pairs of twins over several decades. All in all, the follow-up time of all of the twin pairs corresponds to a staggering 6 million person-years.

    The researchers nevertheless emphasize that there are rare cases of families among whose members SAH is significantly more common than in the overall population. In these cases genetic factors are the principal cause underlying the development of the disease.

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  • From the article:

    • If smoking women with high systolic blood pressure values have 20 times higher rate of these brain bleeds than never-smoking men with low blood pressure values, it may very well be that these women diagnosed with unruptured intracranial aneurysms should be treated. On the other hand, never-smoking men with low blood pressure values and intracranial aneurysms may not need to be treated at all.

    In this largest SAH risk factor study ever, the study group also identified three new risk factors for SAH: previous myocardial infarction, history of stroke in mother, and elevated cholesterol levels in men. The results revise the understanding of the epidemiology of SAH and indicate that the risk factors for SAH appear to be similar to those for other cardiovascular diseases.

    • We have previously shown that lifestyle risk factors affect significantly the life expectancy of SAH survivors, and now we have shown that the same risk factors also affect dramatically the risk of SAH itself.

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  • From the article:

    The study found the lifetime risk of an abdominal aortic aneurysm were: 1 in 17 among all study participants; 1 in 9 among current smokers; 1 in 9 among those in the top third of smoking pack-years (number of cigarettes smoked over a lifetime), whether a current or former smoker; 1 in 12 among current female smokers.

    Researchers also found those who had quit smoking for 3-8 years (recent quitters) still had an approximately 2.6 to 3.5 fold increased risk for both clinical and asymptomatic abdominal aortic aneurysm in the next 15 years compared to never smokers. Their lifetime risk was 6.6 percent higher than long-term quitters.

    For women, authors note the steep increase in risk is particularly concerning given the United States Preventive Services Task Force recommends that current or former male smokers undergo an ultrasound screening for an abdominal aortic aneurysm once between the ages of 65 and 75 but makes no such recommendation for women.

    […]

    The study also found that being older, white, or having high levels of bad cholesterol also increased the risk of abdominal aortic aneurysm.

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  • From the article:

    Researchers have confirmed three gene changes that raise the risk that a blood vessel in the brain will weaken and balloon out (aneurysm), creating a life-threatening chance of rupture. Smoking, the biggest risk factor for brain aneurysm, is five times more dangerous in people with these gene variations. However, a second study on the same population notes that most people with aneurysm die of cancer or heart problems.

    […]

    In one study (Broderick, abstract 156), researchers found that the chance of an intracranial aneurysm increased between 37 percent and 48 percent for people who carried one copy of an identified risky gene variation. However, when the gene variant was combined with smoking the equivalent of one pack a day for 20 years, the risk increased more than five-fold. People with two copies of the gene variant were at even higher risk.

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  • From the article:

    After taking account of influential factors, such as salt intake, working hours, weight and family history of diabetes, smokers were almost three times as likely to have a brain bleed as non-smokers.

    The impact of smoking was cumulative: the longer and more heavily a person had smoked, the greater was their risk of a brain bleed.

    Quitting smoking cut the risk of a ruptured aneurysm by 59% after five or more years – bringing it down to the level of non-smokers. But this was not the case among heavy smokers.

    Those who had smoked 20 or more cigarettes a day were still more than twice as likely to have a ruptured aneurysm as those who had never smoked. […]

    In the short term, smoking thickens blood and drives up blood pressure, both of which can increase the risk of a brain bleed. These effects can be reversed by stopping smoking. But smoking also induces permanent changes in the structure of artery walls, say the authors. These changes may be greater in heavy smokers, they say.

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  • From the article:

    Data from several genome-wide association studies were used to gauge genetic associations to lifestyle and cardiometabolic risk factors. […] According to the analysis:

    -A genetic predisposition for insomnia was associated with a 24% increased risk for intracranial aneurysm and aneurysmal subarachnoid hemorrhage.

    -The risk for intracranial aneurysm was about three times higher for smokers vs. non-smokers.

    -The risk for intracranial aneurysm was almost three times higher for each 10 mm Hg increase in diastolic blood pressure (the bottom number in a blood pressure reading).

    -High triglyceride levels and high BMI did not demonstrate an increased risk for intracranial aneurysm and aneurysmal subarachnoid hemorrhage.

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