Tissue Repair
Episodes
As techniques are developed to differentiate and transdifferentiate cells from one cell type, such as a fibroblast, into another, such as a neuron, interesting patterns of effects on epigenetic age are revealed.
Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, a fascinating phenomenon that offers promise for the idea of rejuvenation in humans.
In this clip, Dr. Peter Attia explains the importance of the amino acid leucine and its role in the mTOR pathway.
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As techniques are developed to differentiate and transdifferentiate cells from one cell type, such as a fibroblast, into another, such as a neuron, interesting patterns of effects on epigenetic age are revealed.
-
Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, a fascinating phenomenon that offers promise for the idea of rejuvenation in humans.
-
In this clip, Dr. Peter Attia explains the importance of the amino acid leucine and its role in the mTOR pathway.
-
Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMDFasting Cancer Obesity Aging Heart Disease Diabetes Insulin Resistance Inflammation Stem Cells Immune System Tissue Repair Autophagy Apoptosis Insulin AutoimmunityDr. Valter Longo discusses fasting as a means to treat or prevent age-related diseases such as cancer, Alzheimer’s disease, and others.
Topic Pages
News & Publications
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BDNF delivery via hydrogel improves respiratory function in rats with spinal cord injury. www.sciencedaily.com
Approximately 17,000 people living in the United States will experience traumatic spinal cord injury in any given year. A severe complication associated with spinal cord injury is the loss of respiratory function, which often occurs due to paralysis of the diaphragm muscle. A 2018 study showed that BDNF delivery to the injured spinal cord improved respiratory function in rats.
Previous research has demonstrated that systemic delivery of neurotrophic factors is associated with many undesirable side effects, such as muscle spasms and chronic pain, and exerts reduced efficacy. The authors of the current study used a water-based gel to deliver a solution of polysaccharide-BDNF particles to spinal cord-injured female rats. This delivery mode keeps the BDNF at the site of injury instead of allowing it to become more widely distributed. Then they measured the action potential in the rats' diaphragm muscle.
They found that the BDNF hydrogel improved diaphragm muscle contractility by more than 60 percent, likely due to BDNF-mediated protection and/or restoration of neurons that innervate the diaphragm.
These findings suggest that targeted delivery of BDNF is a viable strategy for preserving respiratory function following traumatic spinal cord injury.