Q&A #69 with Dr. Rhonda Patrick (4/5/25)
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In this Q&A, Dr. Rhonda Patrick discusses lithium microdosing, reducing homocysteine, aluminum and cancer, beta-alanine, and alpha-lipoic acid supplements. Timestamps include:
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What are the benefits and risks of low-dose lithium supplementation?
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How reliable is sleep tracker data?
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What are the best ways to lower high homocysteine?
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Do you have a deodorant recommendation?
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What lifestyle factors can reduce APOE4-related disease risk?
Is low-dose lithium a promising approach for dementia prevention and treatment?
Lithium is best known for its mood-stabilizing effects, particularly in treating bipolar disorder. However, lithium's narrow therapeutic window—meaning the small margin between effective doses and toxic concentrations—has raised concerns about its use in other contexts. Therefore, there is increasing interest in the potential benefits of low-dose lithium in other health areas such as dementia prevention.[1]
Mechanistic insights: How might lithium protect the brain?
Lithium may support brain health by targeting several important biological pathways involved in Alzheimer's disease. Specifically, it may reduce harmful inflammation in the brain, block an enzyme called GSK-3β which is linked to nerve cell damage, and support brain health by promoting the growth of new nerve cells and production of protective brain chemicals.[2]
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Beginning of Q&A
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Q: Is sauna a workout or a recovery tool? 1
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Q: What wearables does Rhonda use and why? 1
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Q: Are there reliable biomarkers to track lithium's brain effects?
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Q: What is the best source of high-quality sulforaphane?
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Q: How reliable is sleep tracker data? 1
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Q: What is the safest way to get DNA analysis done?
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Q: Does high folic acid intake increase cancer risk? 1
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Q: Is homocysteine included in routine blood work?
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Q: Do you have a deodorant recommendation?
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Q: Should you avoid combining alpha-lipoic acid with berberine? 1
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Q: Why does dairy consumption impede polyphenol absorption? 1
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Q: Do tocotrienols blunt exercise gains like tocopherols do?
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Q: Can pre-workout caffeine lower blood pressure?
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Q: Does glutathione supplementation reduce your own production? 1
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Q: Do CBS SNPs impair tolerance to sulfur-based supplements?
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Watch previously recorded Q&As with Dr. Rhonda Patrick
Q&A #70 with Dr. Rhonda Patrick (5/3/25)
Dr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.
Q&A #68 with Dr. Rhonda Patrick (3/1/25)
Dr. Rhonda Patrick discusses saturated fats and LDL, luteolin's benefits, glyphosate risks, natural vs. artificial flavors, and black cumin seed effects.
Q&A #67 with Dr. Rhonda Patrick (2/8/25)
Dr. Rhonda Patrick discusses microdosing nicotine, GlyNac benefits, intermittent fasting and hair loss, and cold & flu relief.
Q&A #66 with Dr. Rhonda Patrick (1/4/25)
Dr. Rhonda Patrick discusses GLP-1 agonists, alpha-lipoic acid, ubiquinone vs. ubiquinol, calcium needs, and liquid biopsy cancer screening.
Q&A #65 with Dr. Rhonda Patrick (12/7/24)
Dr. Rhonda Patrick discusses _Akkermansia muciniphila_, vitamin B1's effect on blood sugar, emulsifiers in food, and electrolyte supplements.