Telomeres
Episodes
Dr. George Church discusses revolutionary technologies in the field of genetic engineering.
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres.
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Dr. George Church discusses revolutionary technologies in the field of genetic engineering.
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Rhonda Exercise Brain Alzheimer's Cancer Telomeres Probiotics Fasting Pregnancy Coffee Anxiety Dementia Sulforaphane Sauna COVID-19 Supplements Ketogenic DietDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres.
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Dr. Steve Horvath discusses epigenetic aging clocks and their use in predicting biological aging and healthspan.
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Rhonda Exercise Aging Sleep Telomeres Vitamin C Cholesterol Omega-3 DNA Damage Fasting Coffee Magnesium Eyes Calcium Time-Restricted Eating Breast Milk Moringa LactateDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the effects of meditation on gene expression.
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Dr. Elissa Epel discusses potential concerns about supplementation and describes some of the studies that demonstrate the links between healthy lifestyle behaviors.
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Dr. Elissa Epel identifies several biohacks that show promise as strategies to reduce stress and lengthen telomeres.
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Dr. Matthew Walker describes the different chronotypes and the risks associated with adopting a sleep pattern that is contrary to our natural type.
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Dr. Elissa Epel describes the effects of longer sperm telomere length on subsequent generations.
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Dr. Elissa Epel describes how even small lifestyle changes can have an effect on telomere length and healthy aging to compress morbidity.
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Dr. Rhonda Patrick and Dr. Elissa Epel discuss how obesity affects genes in sperm DNA involved in metabolic health and cognitive function.
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Dr. Elissa Epel discusses the pros and cons associated with taking dietary supplements to lengthen telomeres.
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Dr. Elissa Epel discusses how cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal.
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Dr. Elissa Epel discusses the harmful effects of what she calls a "toxic lifestyle," one that includes the consumption of sugar-sweetened beverages.
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Dr. Elissa Epel describes some of the studies that demonstrate the links between healthy lifestyle behaviors like exercise and discusses potential mechanisms.
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Dr. Elissa Epel describes the "low hanging fruit" – small, healthy lifestyle behaviors – that can have positive effects on telomere length and lifespan.
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Dr. Elissa Epel identifies some of the key differences in male and female biology and how they influence telomere length and aging.
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Dr. Elissa Epel gives a brief overview of telomeres and the enzyme telomerase and explains how they impact health and lifespan.
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Dr. Elissa Epel discusses the importance of having an optimal ratio of telomerase to reduce the risk of chronic diseases and cancer.
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Dr. Elissa Epel explains how aging syndromes can be passed to offspring via epigenetic mechanisms.
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Dr. Elissa Epel describes how Mendelian randomization techniques provide insights into the dual nature of telomeres, as both a cause and a sign of aging.
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Dr. Elissa Epel describes the exposome – the totality of non-genetic exposures a person experiences during a lifetime – and explains how it affects telomeres.
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Dr. Elissa Epel describes how toxic stress modulates telomere length.
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Dr. Elissa Epel describes the beneficial effects of education on telomere length in the babies of low-income women.
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Dr. Elissa Epel describes the non-linear effects of exercise on telomere length.
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Dr. Elissa Epel discusses the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.
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Epigenetics Vitamin D Nutrition Exercise Aging Metabolism Sleep Diabetes Telomeres DNA Damage Stem Cells Stress Melatonin Vitamin E Genetics 23andMe Heat Stress Autophagy Autism Folate Sauna AntioxidantOur genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship.
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Dr. Judith Campisi discusses the role of cellular senescence in the aging process and the development of cancer.
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Nutrition Vitamin D Metabolism Diabetes Telomeres Omega-3 Inflammation Depression DNA Damage Stem Cells Micronutrients Mitochondria Autophagy Autism Schizophrenia Resveratrol Sulforaphane Insulin Blue LightDr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience.
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Rhonda explains chronic stress's impact on brain, gut, immune system, and aging. Meditation buffers and improves cognitive and biological aging.
Topic Pages
News & Publications
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Hyperbaric oxygen trial discovered a lengthening of up to 38% of the telomeres, decrease of up to 37% in senescent cells in certain cell populations www.sciencedaily.com
Routine hyperbaric treatment increased telomere length and reduced senescence in humans.
With age, tissues lose their ability to function properly, leading to an increased risk of cancer, cardiovascular disease, and Alzheimer’s disease, among others. Cells become exhausted from replication over time and enter a state of senescence, meaning they will no longer reproduce because they are damaged. Findings of a new report demonstrate the ability of hyperbaric treatments to reduce the number of senescent immune cells.
Hyperbaric (i.e., high air pressure) treatments use increased atmospheric pressure and oxygen content to enhance the total amount of oxygen dissolved in the body, accelerating wound healing. Some forms of routine hyperbaric therapy cause the body to react as if it were experiencing hypoxia (i.e., low blood oxygen), a phenomenon called the hyperoxic-hypoxic paradox. Although some of the hypoxia-associated effects of hyperbaric treatments, such as sirtuin activation, stem cell proliferation, mitochondrial biogenesis, and neurogenesis, are associated with longevity, the effects of hyperbaric therapy on cellular senescence are unknown.
The authors recruited 35 participants aged 60 and older who did not have cognitive decline and lived independently. Participants completed 60 hyperbaric treatments distributed as five sessions per week for three months. Each session consisted of 90 minutes of breathing 100 percent oxygen at a pressure twice that of normal barometric pressure. The researchers collected blood samples at multiple time points to measure markers of senescence in peripheral blood mononuclear cells, which include T cell, B cells, monocytes, and natural killer cells.
By the 30th hyperbaric treatment, participants experienced statistically significant increases in telomere length, a marker of reduced senescence rate, in T-helper cells, B cells, and natural killer cells. Following all 60 treatments, telomere length increased by 30 percent in T-helper cells, 38 percent in B cells, and 22 percent in natural killer cells. Demonstrating further benefit, hyperbaric treatment reduced the number of senescent T-helper cells by 12 percent and cytotoxic T cells by 11 percent after 60 sessions.
These results show, for the first time in humans, that routine hyperbaric treatment reduced the rate of aging in immune cells. However, because this study utilized a small sample, reported large variations in the data, and did not contain a control group, these results must be replicated with future research before they can be fully interpreted.