Nearly half a million women in the US die from cardiovascular disease every year, making early identification of those at risk crucial. Traditional identification methods, which focus on age, blood pressure, smoking status, cholesterol levels, and family history, address short-term risks, but longer-term predictions may improve outcomes. A recent study found that measuring specific blood markers can predict cardiovascular events over a 30-year period in women.

The study involved nearly 28,000 healthy US women. Researchers measured three key biomarkers: high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL), and lipoprotein(a) [Lp(a)]. Then, they tracked the women’s health for 30 years to observe their first major cardiovascular event, including heart attack, stroke, or death from cardiovascular causes.

They found that women with the highest levels of hs-CRP were 70% more likely to experience a cardiovascular event than those with the lowest levels. Similarly, those with the highest LDL and Lp(a) levels were 36% and 33% more likely, respectively, to have a heart attack or stroke. Each biomarker contributed independently to overall cardiovascular risk, with the strongest predictive power coming from a combination of all three markers.

These findings suggest that long-term cardiovascular risk prediction in women can be improved by measuring these biomarkers early in life. This proactive approach could lead to earlier interventions, potentially reducing heart disease risk over several decades.