Bone
Episodes
Dr. Rhonda Patrick discusses her supplement stack, avoiding microplastics, creatine for brain health, and mRNA vaccine autoimmunity risks.
In this clip, Dr. Martin Gibala examines how different HIIT exercises influence bone growth and joint issues.
Dr. Martin Gibala discusses HIIT's health benefits and describes common HIIT protocols.
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Dr. Rhonda Patrick discusses her supplement stack, avoiding microplastics, creatine for brain health, and mRNA vaccine autoimmunity risks.
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In this clip, Dr. Martin Gibala examines how different HIIT exercises influence bone growth and joint issues.
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Dr. Martin Gibala discusses HIIT's health benefits and describes common HIIT protocols.
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Rhonda Vitamin D Microbiome Hormones Omega-3 Melatonin Bone Time-Restricted Eating Cardiovascular SupplementsDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Brad Schoenfeld studies the importance of resistance exercise in maintaining muscle mass.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Sleep Breast Cancer Omega-3 Pregnancy Melatonin Vaccine Curcumin Bone Sauna COVID-19 Ketogenic DietDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Topic Pages
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Red light therapy (photobiomodulation)
Photobiomodulation is a non-invasive, light-based therapeutic technique that stimulates biological processes within cells and tissues, with potential applications in medicine, dentistry, cosmetic procedures, and scientific research.
News & Publications
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Higher fish and omega-3 intake linked to 12 percent lower hip fracture risk. www.nutraingredients-asia.com
Hip fractures can lead to a decline in self-reliance, diminished quality of life, and feelings of depression. However, some research suggests that consuming fish and omega-3 fatty acids influences a person’s risk of experiencing a hip fracture. A 2019 meta-analysis and systematic review found that higher fish and omega-3 intake reduces the risk of hip fracture by as much as 12 percent.
Researchers reviewed the findings of 10 studies involving nearly 300,000 people. Seven of the studies followed people over time (prospective), and three compared groups with and without fractures (case-control).
They found that people who consumed more fish had a lower risk of hip fractures, even when combining the results from prospective and case-control studies. They found the same protective effect for those who consumed higher omega-3s in their diets. Notably, the protective effect of fish and omega-3 intake remained only when considering larger prospective studies (involving 10,000 participants or more) or studies that included body mass index as a factor.
These findings suggest that dietary intake of fish and omega-3s might promote bone health and reduce the risk of hip fractures. Other studies have proposed mechanisms by which omega-3s exert their beneficial effects. For example, one study found that DHA inhibits osteoclast formation and subsequent bone resorption by inhibiting the production of TNF-alpha, a pro-inflammatory molecule. A separate study demonstrated that resolvin, a byproduct of omega-3 metabolism, promotes bone preservation under inflammatory conditions and influences the PI3K-AKT pathway, a major signaling pathway implicated in many human diseases, including osteoporosis.
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Hydrolyzed collagen increases knee joint strength and tendon stiffness by 18 percent. www.frontiersin.org
A new study shows that hydrolyzed collagen strengthens knee tendons in female soccer players. Those who took supplemental collagen experienced an 18 percent gain in knee tendon stiffness, potentially reducing their risk for injury during play.
The study involved 17 elite teenage female soccer players. Half of the players consumed a hydrolyzed collagen supplement plus vitamin C three times a week for ten weeks. The other half consumed a placebo. Both groups participated in a training regimen designed to strengthen the knee and thigh muscles. A team of researchers measured various parameters of the players' knee tendon thickness and strength before and after the intervention.
They found that the players who consumed the supplemental hydrolyzed collagen experienced an 18 percent increase in their knee tendon stiffness. However, they experienced little change in tendon thickness, suggesting that the increase in stiffness was due to changes in the tendon’s material properties subsequent to collagen intake.
Female soccer players are more likely to experience knee injuries than male players, due in part to greater knee joint laxity. These findings suggest that supplemental hydrolyzed collagen support training regimens to bolster knee strength in female athletes.
Hydrolyzed collagen is a mixture of peptides derived from the protein collagen. Evidence suggests that supplemental hydrolyzed collagen consumption improves skin aging, decreases arthritis-induced pain, increases bone mineral density, and decreases hypertension. Learn more about hydrolyzed collage in our overview article.
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Growth hormone cuts fracture risk in half for women with osteoporosis. endocrinenews.endocrine.org
Growth hormone improves bone density and reduces the risk of fractures in women with osteoporosis, according to a 2015 study. Women who received growth hormone were half as likely to experience a fracture over a 10-year period than women who did not.
The study involved 80 women (50 to 70 years old) who had osteoporosis and were taking estrogen-based hormone replacement therapy. Researchers randomly assigned the women to receive daily injections of either a low or high dose of growth hormone for three years or a placebo for 18 months. All the women took daily vitamin D and calcium supplements for the study’s duration. The researchers measured the women’s body composition and bone mass at regular intervals.
They found that women who received growth hormone injections showed marked improvements in their bone mineral density and bone mineral content compared to those who received the placebo. Over the 10-year period, the number of fractures among the women who received growth hormone dropped from 56 percent to 28 percent, whereas fractures among those who received the placebo increased from 8 percent to 32 percent.
Growth hormone, a peptide hormone produced in the pineal gland, promotes growth in childhood and adolescence. During middle age, growth hormone production decreases. Some evidence suggests that because growth hormone is secreted at night (during sleep), not getting enough sleep may hinder growth hormone release, exacerbating age-related bone loss. Learn how body temperature can influence how well you sleep at night in this clip featuring Dr. Matthew Walker.
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Mechanical forces of pressure and movement from exercise increases the formation of bone and lymphocytes, enhancing the ability to clear infection www.sciencedaily.com
From the article:
Researchers from the Morrison laboratory discovered that forces created from walking or running are transmitted from bone surfaces along arteriolar blood vessels into the marrow inside bones. Bone-forming cells that line the outside of the arterioles sense these forces and are induced to proliferate. This not only allows the formation of new bone cells, which helps to thicken bones, but the bone-forming cells also secrete a growth factor that increases the frequency of cells that form lymphocytes around the arterioles. Lymphocytes are the B and T cells that allow the immune system to fight infections.
When the ability of the bone-forming cells to sense pressure caused by movement, also known as mechanical forces, was inactivated, it reduced the formation of new bone cells and lymphocytes, causing bones to become thinner and reducing the ability of mice to clear a bacterial infection.