Since hormetic compounds display a U-shaped biphasic dose-response curve, meaning that at low/optimal doses they improve health and have a “reverse tolerance” effect (get more powerful with frequent use), but at high doses have detrimental effects, I’m wondering whether or not many of the supplements on the market containing high doses of these compounds (Like EGCG, Curcumin, and Resveratrol) are dangerous.

I noticed myself that when taking Curcumin + Piperine at a dose of 1500mg/day, it seemed to have a less noticeable effect the more I used it. I took that as a sign that I should stop using it. Does this seem like too high a dosage, or am I just too worried?

For now I just take whole turmeric with black pepper every morning.

I think people should be careful when buying these supplements since they are only beneficial at certain dosages.