Beta-lactoglobulin is a protein in breast milk. It binds to retinol, a form of vitamin A that plays a crucial role in neurodevelopment, facilitating its transport. A recent study found that nanoplastic exposure induces structural changes in beta-lactoglobulin, impairing retinol binding and transport.
Researchers conducted a multi-part study to investigate the effect of polystyrene nanoparticles on beta-lactoglobulin. First, they measured changes in the protein’s structure and its ability to bind retinol. Then, they examined polystyrene’s effects on lysozyme, an antibacterial protein found in breast milk. Finally, they assessed the effects of polystyrene exposure in worms.
They found that polystyrene nanoparticles induced dose-dependent structural changes in beta-lactoglobulin, impairing its ability to bind to retinol. They identified similar structural abnormalities in lysozyme, driving the formation of amyloid fibrils (abnormal protein clumps). In worms, polystyrene impaired movement, similar to the effects of the neurotoxin paraquat.
These findings suggest that polystyrene nanoparticles alter breast milk protein structures and functions, potentially driving nutritional deficiencies and neurological damage.
Coming soon: a comprehensive overview article on microplastics.
The science digest is a special email we send out just twice per month to members of our premium community. It covers in-depth science on familiar FoundMyFitness related topics.
If you're interested in trying out a few issues for free, enter your email below or click here to learn more about the benefits of premium membership here.