Ketosis
Episodes
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Dr. Dominic D'Agostino discusses how ketones affect exercise performance, reduce inflammation, and improve neurological health.
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Rhonda Vitamin D Gut Ketosis Insulin Resistance Fasting Sulforaphane Intestinal Permeability NRF2 Urolithin ADr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Ketosis Heart Disease Omega-3 Fasting Pregnancy Eyes Muscle Sauna Protein Dairy Intestinal Permeability Brown Fat Moringa SupplementsDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Dominic D'Agostino discusses how ketones affect exercise performance, reduce inflammation, and improve neurological health.
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In this clip, Dr. Mark Mattson outlines the differences between intermittent fasting and a ketogenic diet concerning benefits to the brain.
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In this clip, Dr. Mark Mattson describes how ketone esters may improve brain health.
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Kevin talks about his experiments with a ketogenic diet featuring large amounts of vegetables combined with fats to drive his ketosis and other ideas and projects he is working on.
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In this clip, Tim Ferriss describes his experience with Lyme disease, and how he used the ketogenic diet in conjunction with antibiotics to support his recovery.
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In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the anti-cancer properties of the diabetes drug metformin.
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In this clip, Tim Ferriss describes his efforts to mitigate the risk of Alzheimer's disease by managing his insulin levels using the ketogenic diet.
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In this clip, Tim Ferriss outlines the biomarkers that he measures routinely to make sure his health is on-track while following a ketogenic diet
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In this clip, Tim Ferriss describes the biomarkers that he tracks to fine-tune his health and mental well-being.
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In this clip, Dr. Dominic D'Agostino discusses the importance of an individualized approach when considering glutamine supplementation.
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In this clip, Dr. Dominic D'Agostino describes how gluconeogenesis fills an important role during ketosis to maintain a basal level of glucose.
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In this clip, Dr. Dominic D'Agostino explains how the periodic use of fasting and associated practices may provide health benefits.
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In this clip, Dr. Dominic D'Agostino discusses the therapeutic effects of ketones on cancer growth.
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In this clip, Dr. Dominic D'Agostino discusses the neuroprotective potential associated with a combination of ketones and lactate in the management of traumatic brain injury.
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In this clip, Dr. Dominic D'Agostino describes the positive effects that ketones can have on the brain.
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In this clip, Dr. Dominic D'Agostino discusses the metabolic flexibility of the brain to use various substrates, including ketones, for energy.
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Bioenergetic superiority of ketones and their role in reducing oxidative stress | Dominic D'AgostinoIn this clip, Dr. Dominic D'Agostino explains the interrelationship between ketones and lactate as sources of energy for the brain and the role ketones may have in reducing oxidative stress through greater energetic efficiency.
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In this clip, Dr. Dominic D'Agostino discusses how the body adapts to a ketogenic diet and the possible impacts on age-related chronic diseases.
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In this clip, Dr. Dominic D'Agostino describes the benefits of including fiber from diverse vegetable sources, both cooked and raw, within a ketogenic diet plan.
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In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.
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In this clip, Dr. Dominic D'Agostino describes different approaches that allow the ketogenic diet to be more accessible.
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In this clip, Dr. Dominic D'Agostino describes the parameters that affect an individual's response to ketosis.
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In this clip, Dr. Dominic D'Agostino describes his research into the role of ketosis and ketone supplements in stabilizing brain energy metabolism.
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In this clip, Dr. Peter Attia and Dr. Rhonda Patrick examine the use of various fuel sources in brain metabolism.
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Dr. Valter Longo describes how fasting and the ketogenic diet used together with the standard of care treatment may help treat aggressive cancers.
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Dr. Eric Verdin describes the liver's functions and proposes that the ketogenic diet does not put any undue stress on the liver.
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Dr. Eric Verdin discusses several ways in which NAD+ supplementation can benefit mitochondrial health and play a protective role against aging.
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Dr. Eric Verdin describes how supplementing with exogenous ketone esters may confer some of the beneficial effects of the ketogenic diet.
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Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.
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Dr. Eric Verdin explains how a cyclic or the portion-controlled ketogenic diet is linked to improvements in lifespan and memory in mice.
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Dr. Eric Verdin describes how fasting or a fasting-mimicking diet can influence healthspan and lifespan including discussion of some of the potential mechanisms.
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Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.
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Dr. Valter Longo explains the benefits of a prolonged fast.
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Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.
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Nutrition Alzheimer's Diet Microbiome Sleep Ketosis Omega-3 Fasting Micronutrients Multiple Sclerosis NSAID SaunaDr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.
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Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.
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Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.
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Ketosis Nutrition Brain Alzheimer's Diet Microbiome Performance Insulin Resistance Mitochondria Dementia Insulin SupplementsDr. Dominic D'Agostino discusses the health benefits associated with a modified Atkins diet, ketosis, and supplemental ketones.
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Performance Brain Alzheimer's Cancer Gut Aging Ketosis Insulin Resistance Podcast Cholesterol Inflammation Immune System InsulinDr. Peter Attia discusses dietary strategies to promote longevity and optimal performance.
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Tim Ferriss discusses ketosis, the gut microbiome, and monitoring biomarkers to promote performance.
Topic Pages
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Beta-hydroxybutyrate
Beta-hydroxybutyrate is a ketone body and source of cellular energy produced via the breakdown of fats during carbohydrate scarcity and fasting.
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Butyrate
Butyrate is a short-chain fatty acid produced by microbes in the gut during the fermentation of dietary fiber.
News & Publications
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Ketogenic diet raises brain blood flow by 22% and increases brain-derived neurotrophic factor by 47%, highlighting its potential to support cognitive function even in people without cognitive impairment. pubmed.ncbi.nlm.nih.gov
Glucose has long been considered the brain’s primary fuel, but ketone bodies may offer critical support, especially during periods of low carbohydrate availability. A recent study found that a ketogenic diet boosted levels of brain-derived neurotrophic factor (BDNF)—a key protein that supports brain health—by 47%, highlighting the diet’s potential to support brain health even in people without cognitive impairment.
Researchers recruited 11 healthy but overweight adults to participate in a randomized, crossover study. Each participant followed two different diets: a ketogenic diet high in fat and low in carbohydrates, and a standard balanced diet. Each diet lasted three weeks and ended with brain imaging scans (using MRI and PET) and blood tests to measure brain blood flow and BDNF levels.
They found that the ketogenic diet markedly increased ketone levels in the blood compared to the standard diet. Brain blood flow rose by 22% after eating the ketogenic diet, and BDNF levels increased by 47%. Researchers also found a strong link between ketone levels in the blood and higher brain blood flow.
This was a small study, but the findings suggest that a ketogenic diet enhances brain blood flow and boosts vital brain-supporting proteins, even in people without memory loss. This opens up new possibilities for using ketogenic nutrition as a strategy to preserve cognitive function and support long-term brain health. Learn how to plan the optimal ketogenic diet in this clip featuring Dr. Dominic D'Agostino.
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A ketogenic diet may be beneficial for people with brain tumors. www.sciencedaily.com
Glioma is a collective term for tumors that arise from the glial cells in the brain. Astrocytoma, the most common form of glioma, arises from star-shaped cells in the brain called astrocytes. The the survival rate for glioma, including astrocytoma, is low. Findings from a recent study suggest that a ketogenic diet is beneficial for people with astrocytoma.
Ketogenic diets are low in carbohydrates and high in proteins and fats. They cause the body to oxidize fats to produce ketones for energy. For many years, ketogenic diets have been used in the clinical setting to reduce seizures in children. They are currently being investigated for the treatment of cancer because evidence suggests that cancer cells cannot use ketones for energy.
The eight-week intervention study involved 25 people with astrocytoma whose disease was stable following chemotherapy. Participants followed a weekly dietary protocol consisting of five days of a ketogenic diet (consuming 20 grams or less of carbohydrates per day) and two non-consecutive days of fasting (consuming less than 20 percent of their estimated caloric needs). Participants kept food diaries and provided weekly blood and urine for measuring ketones, insulin, glucose, hemoglobin A1c (a measure of long-term blood glucose control), and IGF-1. They underwent brain scans at the beginning and end of the intervention.
About half of the participants adhered to the dietary intervention, which was well-tolerated and elicited few adverse events. Despite the relatively low compliance, all the participants had ketones in their urine, with 80 percent achieving moderate levels. Participants' hemoglobin A1c, insulin, and fat body mass decreased, but their lean body mass increased. No changes were noted in glucose or IGF-1 levels. The brain scans showed that ketone concentrations increased in the brain (including the tumor tissue) and correlated with ketone levels in the urine.
These findings demonstrate that a ketogenic diet is safe for people with astrocytoma and may be beneficial as adjunctive therapy. Learn more about how a ketogenic diet, combined with fasting and the standard of care treatment, may help treat aggressive cancers in this clip featuring Dr. Valter Longo.
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Beta-hydroxybutyrate, a ketone, increases brain-derived neurotrophic factor expression: relevance for neurodegenerative disease www.sciencedaily.com
β-hydroxybutyrate production consequent to exercise induces within the muscle the activities of a key promoter involved in the production of brain-derived neurotrophic factor.
From the article:
Studies have shown that BDNF levels in the brains of people with Alzheimer’s or Huntington’s disease are, on average, half that of people without either brain-damaging disease.
Among the key findings of the current study was that a ketone, a chemical naturally produced in the liver called beta-hydroxybutyrate (DBHB), triggers biological reactions that activate the BDNF gene to produce more of its protein. DBHB has long been known to build up in the body and brain with exercise. Ketones are “by-product” chemicals made when animals break down fat as an alternative energy source after having drained more readily available sugar stores during exercise.
Specifically, Chao says, the researchers found that DBHB prevents other proteins in the brain known as histone deacetylase complexes, or HDACs, from suppressing BDNF production by altering the environment of the BDNF gene.